#1264 Weekly News 7/22/24

July 28, 2024Scott Benner

For the week of July 22, 2024

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Scott Benner 0:00
Hello friends and welcome to episode 12 164 of the Juicebox Podcast.

So quick in and out, this is the News for the week of July 22 2024. I picked out a few stories that I found interesting, not the least of which is Lance Bass from in sync as diabetes all of a sudden, nothing you hear on the Juicebox Podcast should be considered advice, medical or otherwise, always consult a physician before making any changes to your health care plan. If you have type one diabetes are the caregiver of someone with type one and you're a US resident, please, when you're done with this episode, it's going to be 10 minutes this episode and then take 10 more minutes to complete the survey AT T one D exchange.org/juice. Box support yourself. support other people with type one diabetes, support me support Lance Bass, he won the exchange.org/juice box just complete the survey. It's all you need to do and you're and you've helped. That's it, it's going to be helpful. Don't forget, if you use my link drink ag one.com/juice box you'll get a free year supply of vitamin D and five free travel packs with your first order. And if you go to cozy earth.com and use the offer code juice box at checkout, you're gonna save 30% off of your entire order. Listen, just wait till August the percentage is going to go back to 40 and cozy Earth. Don't tell them I told you this is the diabetes news I found interesting for the week of July 22 2024 Welcome back everybody. Not a long one today but an interesting one. This first part is from science.org in an article titled The benefits of GLP one drugs beyond obesity glucagon, like peptide one based medicines have weight loss independent actions. Here's the breakdown of that GLP one function of course, glucagon like peptide GLP. One is secreted from gut endocrine cells in response to food ingestion and enhances glucose dependent insulin secretion. GLP one receptor activation reduces glucagon secretion slows gastric emptying and helps in weight management. This is things by now a lot of you know early GLP one therapies like eggs net tide and liar Gula tide sorry, required daily administration where the whereas these new versions, like semaglutide, for example, allow for weekly doses. Now there's cardiovascular benefits. These agonists have shown significant cardiovascular benefits such as reducing the risk of non fatal stroke, myocardial infarctions and cardiovascular deaths in people with type two diabetes and obesity. Okay, so maybe it's because they lost weight but maybe it's maybe it's something else. It also shows heart protection GLP one therapies protect the heart independently of glucose control or weight loss AHA demonstrated in both diabetic and non diabetic animals inflammation reduction GLP one drugs help reduce systematic inflammation, which may contribute to their cardiovascular benefits. This anti inflammatory effect is partially mediated through new GS neuronal GLP one our activation I have no idea that is around your liver and kidney health GLP one R is involved in approving liver and kidney function, though the exact mechanism particularly in the liver health are still being studied. What about neuro protections GLP one drugs have shown potential in reducing neuro inflammed inflammation and protecting against neurodegeneration in conditions like stroke and nurture, and neuro degenerative diseases. Trials indicate that GLP one therapies may have benefits in reducing rates of cognitive dysfunction, substance use disorder and possibly even psychiatric conditions like depression and compulsive behaviors. And if you heard the episode, I think two weeks ago, there's a mom on there telling the story of how it was very helpful with her child's bipolar disorder. They say here the next generation therapies, new GLP one based therapies are being developed, often combined with other receptor agonists like G IPR and glucagon receptor, excuse me glucagon receptor to enhance efficacy and provide greater weight loss and cardio metabolic benefits. Expanded uses you may see in the future ongoing research aims to extend the use of GLP one therapies beyond diabetes and obesity to other chronic conditions, including liver kidney disease and various neurological and psychiatric disorders. I think gives you a little conclusion here it says GLP one drugs have evolved from primarily treating diabetes to offering broad health benefits including significant cardiovascular renal neurological protection, future research and development are poised to expand their therapeutic application further remember years from now when this stuff is helping with so many things, you heard it from me first little story here from Helio news overview to come the fast okay the FDA Fast Tracks designation for diamonds immunotherapy. The FDA has granted Fast Track designation to the drug are H G ad six five slash alum, this is from diametre the I A mid an antigen specific immunotherapy developed by the diamond diamond medical. This designation aims to expedite the development and review of the drug trip targeting excuse me, children with stage one or stage two type one diabetes who carry the HLA Dr three DQ two genotype, Say that five times fast. Oh, the purpose here is designed to preserve endogenous insulin production. It works by delivering recombinant gad 65 proteins interal, emphatically How'd I get that right, which helps the immune system tolerate the body's insulin production producing beta cells rather than attacking them. Die made is currently being evaluated in the diagnose a three phase three trial, which is randomized placebo controlled study involving approximately 330 patients ages 12 to 20 years old who were recently diagnosed with type one diabetes and carry the HLA Dr three DQ two genotype. Wow, the trial was just a lot. The trial aims to measure changes in blood glucose levels and the function of beta cells over 24 months. So the significance of this fast tracking here says this is the second Fast Track designation for Diamond this year emphasizing its potential to delay the onset of clinically diagnosed type one. Previous designations for for treating individuals with stage three type one diabetes, innovation. some talking points here represents a novel approach by targeting specific genetic profiles to prevent or delay the progression of type one diabetes, it is pretty specific, ongoing phase three trial, and preventative studies highlight the significant strides being made in developing effective treatments for type one diabetes. Of course, this is a human study, not a mousy thing, which is nice to hear. Let's ask our friends here at Chad GPT a question. Just going to ask if this trial is still open to participants. So let's see what I can figure out very quickly for you in case you're interested. It's doing it's looking scouring. Oh yes, the diamond trials currently open to participants. Here are the details. The participants will receive three intro intro lymphatic injections of diamond or a placebo given one month a part of the primary efficacy endpoints are the preservation of endogenous insulin production and improve blood glucose control. Looks like you can go to the website dy mid D ay ay myd.com. The phase two open label trial evaluates the safety of feasibility and the participants the trial aims to enroll 10 to 16 children ha day team study will involve two to three injections. Yeah, you guys should check it out. If you're interesting. Both trials are actively recruiting and you can find out more information expressed interest in participating by visiting the respective trial websites or content or contacting diamond medically. Diamond medical directly. Can I get a URL? I would it tell me I could contact the URL but then not tell me the URL. It Chachi so silly diag and OD dash three.com. That's the diagnosed three phase three trial. And general information about dynamic clinical trials di m id.com. Forward slash Doc's TOC s forge slash clinical trials dot ASP x looks like it's going to bring up a forum for you. If you're interested, check it out. Or you can just Google it di m ID trials dia M yd. And here's some breaking news. Oh, this is really news. But you know, Lance Bass from the band in sync. Turns out he's got Lada and he's talking about it. So very new information. By the way BP BP BP is breaking news. Okay, let's see. Lance Bass discusses this trick image management imposed by his management team since it's time within sync. He was forced to hide his sexuality or Okay, well that's got nothing to do with diabetes. So it's like wait, where's the part about the diabetes?

During the COVID 19 pandemic back bass was diagnosed with diabetes. He is now learning to manage his condition focusing on his diet exercise and insulin regime. This diagnosis has made him more conscious of his health and lifestyle choice last pass you want to be on the diabetes podcast baby baths enjoy spending time with his husband and their twins. Man How is it possible you could give me an article about Lance Bass tell me more about the diabetes oh my what a common story it happened to our own Lance Bass he was misdiagnosed as a type two says he's still coming to terms with his latest diagnosis. Bass already feels more empowered living with type 1.5 which is also returned referred to as latent autoimmune diabetes we know what a lot is you don't have to tell us quote I'm type one and a half which I had no idea was a thing until a few weeks ago you and everybody else maybe but you know I'm interested in fascinating to me finding the whole new level diabetes had no clue about it's not unusual at somebody with type one and a half which usually occurs later in life is initially misdiagnosis. Type two says the Mayo Clinic you could have asked me that I could have told you the same thing. Differences that one and a half is a result of an autoimmune disease here we know all this. What? I didn't realize that it was one and a half. He says I was out there doing a bunch of stuff that wasn't helping him. Okay. Well, you guys jump up on the social medias and ping Lance Bass tell him we want him to come on the podcast tell a story so we can figure out they're interesting. Lance Bass got type one and a half. I'd love to ask him about his life. That'd be fun. Alright, kids, listen. I'm gonna jump. Okay, I hope you found these interesting. I hope you're enjoying the news segments. 10 minutes, I feel like is a nice little bit. That's all I got for you today. Hey, this isn't really an ad but screen for type one is the sponsor. And after one of those stories in there, I thought maybe you guys would want to know about it screened for type one.com You should check it out. If you want to find out how to get your loved ones and even extended extended memories, sorry, extended members of your family that I blend together member and family and come up with memories. That's crazy. screen for type one.com There's a link in the show notes. I was looking for a way that we could all get nice and tan and meet each other and spend some time talking about diabetes. How are we going to do that on a juice cruise? Juice cruise 2025 departs Galveston, Texas on Monday, June 23 2025. It's a five night trip through the Western Caribbean visiting of course Galveston, Costa Maya and Cozumel. I'm going to be there. Eric is going to be there. And we're working on some other special guests. Now, why do we need to be there? Because during the days at sea, we're going to be holding conferences. You can get involved in these talks around type one diabetes, and they're going to be Q and A's. Plenty of time for everyone to get to talk, ask their questions and get their questions answered. So if you're looking for a nice adult or family vacation, you want to meet your favorite podcast host but you can't figure out where Jason Bateman lives. So you'll settle for me. If you want to talk about diabetes, or you know what, maybe you want to meet some people living with type one, or just get a tan with a bunch of cool people. You can do that on juice cruise 2025 spaces limited. Head now to juicebox podcast.com and click on that banner. You can find out all about the different cabins that are available to you. and register today. links in the show notes links at juicebox podcast.com. I hope to see you on board. I know that Facebook has a bad reputation. But please give the private Facebook group for the Juicebox Podcast. A healthy once over Juicebox Podcast type one diabetes. The group now has 47,000 members in it, it gets 150 new members a day. It is completely free. And at the very least you can watch other people talk about diabetes, and everybody is welcome type one type two gestational loved ones, everyone is welcome. Go up into the feature tab of the private Facebook group. And there you'll see lists upon lists of all of the management series that are available to you for free in the Juicebox Podcast, becoming a member of that group. I really think it will help you it will at least give you a community. You'll be able to kind of lurk around see what people are talking about. Pick up some tips and tricks. Maybe you can ask a question or offer some help Juicebox Podcast type one diabetes on Facebook. Hey, thanks for listening all the way to the end. I really appreciate your loyalty and listenership. Thank you so much for listening. I'll be back very soon with another episode of The Juicebox Podcast

I don't really have anything to put here. But the music It just always goes at the end. You know? I don't know what I should be talking to you about really? Hey, you know what, here's a super simple thing. If you want the list of all the management series, they are pinned in the featured tab of the private Facebook group, or you can find them in the menu at juicebox podcast.com. That seems to be a thing people ask about all the time and have trouble finding. Of course, if you're listening now online or on YouTube, please subscribe or follow in an audio app like Apple podcasts, Spotify, Amazon music, something like that. It helps the show and if you love it, leave a review make it five stars and say something cool that would make somebody else want to try out the Juicebox Podcast