#1252 Weekly News 7/8/24

July 16, 2024Scott Benner

Weekly News 7/8/24

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Scott Benner 0:00
Hello friends and welcome to episode 1252 of the Juicebox Podcast

Welcome back this is some diabetes news for you from the week of July 8 2024. Nothing you hear on the Juicebox Podcast should be considered advice, medical or otherwise, always consult a physician before making any changes to your health care plan. When you place your first order for ag one with my link, you'll get five free travel packs and a free year's supply of vitamin D. Drink ag one.com/juice box. If you'd like to save 30% off of your entire order at cozy earth.com All you have to do is use the offer code juice box at checkout I dried myself just recently with some beautiful waffle towels from cozy Earth and my baits and my bagels were all very happy about it. Yours could be to pat yourself dry and comfort and quality cozy earth.com use the offer code juice box. I don't they don't tell me what to say by the way I just I say whatever comes to my head. And listen if you have type one diabetes or you're the caregiver of someone with type one and you're a US resident, You'd be doing me you and pretty much the whole world a favor if you went to T one D exchange.org/juicebox joined the registry and completed the survey take you about 10 minutes T one D exchange.org/juicebox podcast this episode of The Juicebox Podcast is sponsored by me because I'm here to tell you about the juice cruise 2025 That's right. I have introduced a vacation for all of us with diabetes. Families I say all of us because I'm the father of someone with type one. So we're looking for families or adults. People with type two diabetes gestational if you have a connection to diabetes, and you want to go on a vacation was with a bunch of cool people who are going to really understand your life. Get a tan see Mexico hang out talk diabetes, go to Q and A's all this cool stuff. juicebox podcast.com Scroll down just a little bit to the juice crews banner, click on it there you'll find out all about registration. I think there's an early bird, bird, right? Why can I say early bird early bird special if you sign up? I think you gotta put your deposit down before August 1 To save something. You'll see it when you get there. juicebox podcast.com Just scroll down a little bit click on the banner. What's up kids? We're gonna do a news thing for you. Today is July 12. It's got his birthday, and I'm gonna read you the news. Let's start with this article. Distinct T cell signatures identified in children with type one diabetes. This is from News Medical Life Sciences. I don't know news dash medical.net. So here's the here's the skinny right. A recent study published in news dash medical has identified distinct T cell signatures in children with type one diabetes. T cells are a type of white blood cell that plays a crucial ro ro role in the immune response. I'm not getting that out. This study discovered unique patterns of T cell activity in children with type one diabetes, as compared to healthy children or kids who don't have type one. Research conducted detailed analysis of blood samples from children with type one and those without they used advanced techniques to identify and compare T cell populations and their activity levels. And the study found that specific T cell subsets were more prevalent and active in children with type one diabetes. Now, the implications of that are this. The findings suggest that certain T cells may contribute to the development and progression of type one. And they think that understanding T cell signatures could lead to new diagnostic tools, and maybe even allow for earlier detection of diabetes. This of course, might pave the way for targeted therapies aimed at modulating the immune response to prevent or slow down the destruction of beta cells. Pretty cool. Now, you're saying but Scott, what is a T cell? Okay, so a T cell or a T lymphocyte lymph cell lymphoma cell? I don't know. I'm not a doctor. I'm just interpreting the news. These T cells are essential for the adaptive immune response, which is the body's targeted defense against specific pathogens they help recognize and eliminate infected or cancerous cells. There are hyper T cells. The cells assist other white blood cells in immunological immunologic processes, including the activation of B cells to secrete antibodies and macrophages. Okay, to destroy ingested microbes. ingest the microbe, they go get it. What's a microbe we can deep dive if you want to, but cytotoxic T cells are another one these cells directly attack and destroy infected or cancerous cells and regulatory T cells help regulate or suppress other cells. To the immune system preventing autoimmune diseases. Okay, so that's what a T cell is. Now go back up to the study. The lead researcher emphasizes the importance of the findings in understanding the immune landscape for type one. And they noted that this research could help identify at risk individuals before clinical symptoms appear. I'd be very cool for early intervention. The study is a significant step forward in the quest to unravel the complexities of type one diabetes, continued research in this area holds promise for developing better diagnostic and therapeutic strategies. And of course, maybe more will come one day. Pretty cool, right? That's not bad. So that's that article. Now let me get rid of that one and get to the next one that I thought we'd talk about. Okay. There's a trial that you can get involved in the V x two, six. Why are people texting me while I'm trying to talk to you about the news? It's just a reminder to pick up a prescription, which is what I'm going to do when I'm done here. Now I'm going to be later because of the text. Ironic, no. Okay, the VX 264 trial. Let's find out more about it. This trial is researching Iceland cell transplants. Hmm, okay. Let me get you that info Meishan and where to go check it out vert. This is vertex by the way. And let's see where can you find out of this find out more about the trial? Yes, I will. Okay. So it is 264 dot t one study.com. By the way, I have no affiliation with this study. investigational therapies for type one so this is a study you might be able to get involved in. I thought this might be interesting to you. 264 dot t one study.com. The upward study is looking for individuals living with type one diabetes to participate in a study of an investigational cell based therapy. This is right from the website. The investigational therapy consists of cells designed to produce insulin contained within devices designed to protect the cells from the immune system sounds like a pouch kind of thing. investigational devices are implanted in the space behind the muscle of the abdomen wall. researchers are studying the safety tolerability and effectiveness of international health. Well, if you're interested in this, go check it out. It's the upward study type one diabetes clinical trial. And I've read you the the link a couple of times. I'm not gonna lie to you. I won't be putting the link in the show notes. But you can go back and listen and type it in for yourself if you'd like to learn more. When let me see if I can learn a little bit more about the upward study. All right. The upward study is investigating and investigational cell based therapy for type one diabetes, the eligibility is 18 to 65 years old diagnosed with type one diabetes, requiring insulin injections or pumps. Well, okay, well, I can probably most of you. Go check it out and see what you think. You know, if you get involved in the study, let me know he just looks like he just has like a three step process to find out if you're eligible. Go check it out. I've had people on who have done implantable studies before and had really great success. I'd be happy to tell you what episode that is, but I really don't remember. I know you're like well, if he told me it's got to go listen to it, but I don't have that kind of time today. All right, what else did we see in the news today around the type one diabetes? Oh. How about this one? This little ditty. GLP drugs like ozempic may reduce the risk of these 10 cancers. 10 Let's find out more. Oh, there's so much reading here. Watch how I'm gonna cheat. I'm gonna paste it and say, give me bullet points. Let Chad GPT read that link. It's read. And now. Bada bing. Here comes the bullet points. It's that fast live. Let's see what we have here. Okay, a study overview. Here's the study over you researchers analyzed over a decade of medical records from nearly 1.7 million people with type two diabetes to investigate the effects of GLP one drugs on cancer risk.

significant risk reduction. Check this out, kiddies. Gallbladder cancer reduced by 65% minute Jimmy OMYA by 63%. I probably didn't pronounce that right. Pancreatic cancer reduced by 59%. Well, that's lovely. Liver cancer reduced by 53 Ovarian by 48 colorectal. I only know how to say that because of commercials where they say colorectal cancer reduced by 46% because it looks like color Actel you know what I mean? Multiple Myeloma bone marrow cancer reduced by 41%. esophageal cancer 40 percents just hear me just roll out esophageal like it was nothing. endometrial cancer of the uterine lining reduced by 26%. Oh gosh, kidney cancer reduced by 24. Wow, it did not seem to significantly reduce the risk for postmenopausal breast cancer, stomach cancer or thyroid cancer. It says here the reduction cancer risk is thought to be linked to the GLP ones drugs effects on insulin production, chronic inflammation and hormone levels, which are factors involved in cancer development. God damn right. How about that? Should we be clapping? Now the study did face limitations due to its retrospective nature and reliance on electronic health records, which can include diagnostic inaccuracies and uncontrolled variables. Further research is needed. Boy, I'll tell you what. I'll tell you what I got up this morning weighed myself. This is the lowest I've weighed since I started a GLP. Med a year and a half ago. On my birthday, it was a nice little nice little birthday surprise. Before I get to the last story, I just want to jump in to tell you this. I'm hosting a cruise in June of 2025. It's called just cruise 2025. Go to juicebox podcast.com. Scroll down a little bit, click on the banner, it will take you right to the website where you can find out the itinerary, all the cruise information and put a deposit down in your cabin if you like. It's selling very well. And there are limited spaces. So if you're actually interested, you putting your deposit down now of course would be the way to go. We were only able to secure a certain number of cabins and a certain number of spaces. There's going to be me Eric is coming working on getting you one other person for talks. So there'll be conversations around type one diabetes, we'll be giving talks like straight from the podcast, and of course answering questions, tons of q&a, working on having some people there from different companies to answer questions for you about devices. And other than that sun and fun around Mexico. Getting a tan with a bunch of cool people have diabetes. So check it out. Go to juicebox podcast.com. Just scroll down a little and click on the banner for the Juicebox Podcast cruise. Doesn't matter if you're a family with type one or an adult everyone's welcome. You have type two, come on. Let's go you got diabetes. We want to meet you. There is a $25 on Boyd on Boyd onboard credit per state room if you register by August 1. I thought this NPR article was interesting. I'm going to share it with you it's from June 2024. It's called your gut microbes may influence how you handle stress. Here's some key points from it. A study published in natural Mental Health found distinct biological signatures in the microbiomes of individuals who are highly resilient to stress. You may recognize the word resilient here, I just put up a four part series with Erica Forsythe about resilience. And that's why this caught my eye. Hi resilio resilience was linked to anti inflammatory microbes and improved gut barrier integrity. The gut microbiome communicates with the brain via the immune system, vagus nerve neurotransmitters and short chain fatty acids. And that's really cool, isn't it? Like there's not much more to it than that. But that's I thought that was kind of awesome. It says future research aims to develop microbiome based therapies to mitigate stress and mental health disorders. Oh, I thought that was awesome. It's called your gut microbes may be influencing how you handle stress. If you want to Google it. It's bile. Let's see. I'm wonder if I could. Yeah, I think this is pretty cool. I don't know I'm interested in stuff like this. I thought you would be too. Alright, that made me go find this article. This is Medical News. Today. It's a year or so old, but it's called the role of the gut microbiome. Actually, what's the article called? Type Two diabetes researchers identify gut bacteria linked to insulin sensitivity. Among other things, it says cedar cyanide researchers found that people with higher levels of gut bacteria from a group called copra caucus tend to have higher insulin sensitivity. Additionally, they discovered the gut microbiomes with higher levels of flavor. Oh, I Fraktur tended to have lower insulin tended to have lower insulin sensitivity in that in that interesting, like, how could you get more? Alright, let me ask the chat. GPT. Overlord, how can I get more copper caucus in my gut? To increase copper caucus in your gut, you can try the following methods diet consumer diet rich and fiber including fruits. Okay, probiotics, prebiotics, limited processed foods, regular exercise, avoid antibiotics, okay, I feel like that stuff we already know. But can I just like, is there a way to give myself a let's call On a turbo boost of copper caucus. There isn't a specific guaranteed method for rapidly increasing the levels. He sends me right back to this. Where is copper caucus found? I'm mispronouncing it. By the way, type of bacteria commonly found in the human gut plays a role in producing short chain fatty acids, important for gut health. This bacterium thrives in environments such as dietary fiber, so consuming High fiber foods can support its growth. And doesn't say it's not like eat this thing and you'll get it. Is it found in any supplements? It's thinking it's not commonly found in commercial probiotics. I'll be damned. Well, let's get on that. Should we? Anyway, interesting article. Like I said, Medical News Today type two diabetes researchers identified gut bacteria LinkedIn insensitivity. All right, everybody. That was fun. I'll be back next week with another one of these I got a lot of emails from people who said they were enjoying these. I appreciate you guys listening. I'll find you some more stuff to talk about next week.

Scott reads the news was brought to you by juice Cruz 2025 Go to juicebox podcast.com. Scroll down and click on that juice cruise banner and put down your deposit comes cruising with me. And all my friends. We're gonna meet, chat, have fun, relax, make lifelong. Maybe somebody will get married from the cruise or have a baby. I'm finally gonna get a baby named after me. juicebox podcast.com gmail.com Don't put an R in there. juicebox podcast.com Go check out the juice cruise. I hope to see you on the ship in June 2025.

If you or a loved one was just diagnosed with type one diabetes, and you're looking for some fresh perspective, the bold beginning series from the Juicebox Podcast is a terrific place to start. That series is with myself and Jenny Smith. Jenny is a CDC es a registered dietitian and a type one for over 35 years. And in the bowl beginning series Jenny and I are gonna answer the questions that most people have after a type one diabetes diagnosis. The series begins at episode 698 In your podcast player, or you can go to juicebox podcast.com and click on bold beginnings in the menu. Thank you so much for listening. I'll be back soon with another episode of The Juicebox Podcast. If you're looking for community around type one diabetes, check out the Juicebox Podcast private Facebook group Juicebox Podcast type one diabetes, but everybody is welcome type one type two gestational loved ones. It doesn't matter to me. If you're impacted by diabetes and you're looking for support, comfort or community check out Juicebox Podcast type one diabetes on Facebook