Omnipod® Horizon™ System Significantly Improves Glycemic Control in Patients with Type 1 Diabetes

Good news for the future from Omnipod!

BILLERICA, Mass.--(BUSINESS WIRE)--Jun. 24, 2018-- Insulet Corporation (NASDAQ:PODD) (Insulet or the Company), the leader in tubeless insulin pump technology with its Omnipod® Insulin Management System (Omnipod System), today announced that positive results from the most recent clinical trial of the Omnipod® Horizon™ Automated Glucose Control System (Omnipod Horizon System) were presented during the American Diabetes Association (ADA) 78th Scientific Sessions in Orlando.

The study demonstrated that the Omnipod Horizon System performed well and was safe for over five days of use in adults, adolescents, and children with type 1 diabetes.

“In the era of personalized medicine, Insulet is committed to bringing our innovative technology to the global diabetes community and our clinical data give us confidence that the Omnipod Horizon System will be a significant advancement in diabetes management.”

— Dr. Trang Ly, Senior Vice President and Medical Director

The study was conducted in a supervised hotel setting under free-living conditions with unrestricted meals and moderate-intensity exercise and included patients who use multiple daily injections or traditional tubed insulin pumps as their standard therapy. Study participants spent significantly less time in hypoglycemia, more time in the target glucose range and had better overnight glycemic control compared to their standard therapy. The investigational device includes features that allowed study participants to customize their diabetes management by adjusting their target blood glucose levels and insulin delivery.

“We recognize that everyone’s treatment needs are different, and the Omnipod Horizon System provides individualized diabetes management to address real world challenges,” said Dr. Jennifer L. Sherr, MD, PhD, of Yale University School of Medicine. “One of the important features is the ability for users to tailor the system for exercise and high fat meals to maintain good glycemic control.”

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During the study, glucose control was maintained in the target range (70 to 180 mg/dL) between 69% and 79% of the time overall, and between 74% and 85% of the time during the overnight period, across all age groups. Hypoglycemia was very low overnight, ranging from 0.7% and 1.3% of the time, across age groups.

“In the era of personalized medicine, Insulet is committed to bringing our innovative technology to the global diabetes community and our clinical data give us confidence that the Omnipod Horizon System will be a significant advancement in diabetes management,” said Dr. Trang Ly, Senior Vice President and Medical Director. “We are very pleased that for the second consecutive year, Omnipod Horizon System research was highlighted in the official ADA Press Program based upon its overall excellence in furthering research and advancing treatment for people with diabetes.”

The rest of the article is here

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Daylight Savings Time

Don’t forget -- your microwave isn't the only clock that requires adjusting tonight.

The clocks in your meters, insulin pumps and CGMs need to ‘Spring Forward’ as well… #diabetes #daylightsavingstime

Important: Some insulin pumps may not offer bolus calculations for a period of time after you make clock adjustments.

PHOTO: National Geographic - news.nationalgeographic.com

Photo of a man adjusting giant clocks. Peter Shugrue checks a clock at the Electric Time Company factory in Medfield, Massachusetts, on March 8, 2013.

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Juicebox Podcast

Omnipod of the Future Revealed

Omnipod had a shareholder meeting this week and the slideshow that accompanied it was full of interesting stuff...

Timeline for new products and innovation 

Exciting!

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Relationship with Lilly to bring concentrated insulin

Looks like concentrated insulin keeps form factor small while adding enough insulin for people with greater needs...

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New Bluetooth PDM and an Artificial Pancreas 

Looks like the plan is to first release the Dash (new PDM) followed by the Horizon Artificial Pancreas system...

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The entire slide deck can be found here, it has lots more info and business type stuff. I only brought you the exciting diabetes tech images. I need to get an Omnipod representative back on the Juicebox podcast. Good times ahead folks, good times! Lots of questions...

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First Patients Enrolled in Clinical Trial for Omnipod Artificial Pancreas System

Look out future... Here come the Podders!

from Buisnesswire

BILLERICA, Mass.--(BUSINESS WIRE)--Insulet Corporation (NASDAQ:PODD) (Insulet or the Company), the leader in tubeless insulin pump technology with its Omnipod® Insulin Management System (Omnipod System), today announced the first patient has completed the feasibility study of the Omnipod Horizon™ Automated Glucose Control System (Omnipod Horizon System). The full study will evaluate the use of a personal Model Predictive Control algorithm with the Omnipod platform in 20 adults with type 1 diabetes and is taking place in a clinical research center setting to gather data to be used to evolve the algorithm in subsequent studies leading to FDA submission.
“We are very excited to be participating in Insulet’s artificial pancreas clinical trials,” said Jordan Pinsker, M.D., senior research physician at William Sansum Diabetes Center. “Working with Professor Francis J. Doyle III and Dr. Eyal Dassau, Sansum played a major role in the development of the original UC Santa Barbara Artificial Pancreas algorithm that Insulet acquired. We look forward to contributing to the clinical and development pathway as Insulet takes this promising technology to a commercial product.”

The Omnipod Horizon System will combine best-in-class technologies into one integrated system consisting of an on-body Omnipod tubeless pump, the latest Dexcom continuous glucose monitoring (CGM) technology, a modified version of Insulet’s handheld controller and state-of-the-art security system architecture. Insulet’s Omnipod Horizon System is unique in that the algorithm looks toward the future horizon of blood glucose levels, reacting quickly and efficiently to adjust insulin delivery to optimize outcomes for each user. The system will provide the same proven lifestyle benefits as the current Omnipod System, such as the discreet, reliable, tubeless form factor and up to three days of non-stop insulin delivery to make it easy to stay connected and avoid disruption of insulin delivery during routine activities like exercising and bathing.

“Our new Omnipod Horizon System is designed to deliver not only improved clinical outcomes, but the greatly desired improvement in quality of life for those living with insulin-dependent diabetes,” said Patrick Sullivan, President and Chief Executive Officer. “With the first clinical study of our innovative artificial pancreas underway, we have taken another important step in fulfilling our mission to improve the lives of people with diabetes.”

The entire article can be found here.

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A1C: How We Got To 5.7

I've written blog posts for years about how we've reduced Arden's A1c. I've told you about the OmniPod insulin pump, DexCom continuous glucose monitor, modifying diet, being bold with insulin and more. The process has existed on many paths. We had to conquer school days, overnights, carb rich foods, sports and my fear of insulin. If you search the phrase "A1c" on this site a bevy of blog posts will return and they all highlight a moment of the journey. You'll see us get out of the 9's, the 8's the 7's and finally claw our way to sub 6. 

Almost each time that we got the number to decrease I would spend the ride to Arden's endo appointment telling her not to be disappointed if her A1c goes up because I was always trying things and never really sure if they would work. Diabetes is the ultimate on the job training

Last weeks Endo visit was different...

When we got into my car I told Arden, "Your A1c is going to be 5.7, watch and see". I was confident, almost brash when I told her this. Sure I was cheating a little - truth be told - because I have the Dexcom Clarity app on my phone and can see Arden's A1c. But still my confidence was rooted more than just being able to see reports from her glucose monitor ahead of her quarterly blood test. This confidence was bigger than data because I finally know what I'm doing. No more guessing, no more wondering. Today I trust my gut and we attack Arden's blood sugars with a steely resolve. All of our experiences have finally added up and the seemingly senseless actions of diabetes are finally making sense.

The way I arrived at this resolve is why I'm writing today...

In the Spring of 2015 I launched a type 1 diabetes podcast called the Juicebox Podcast. My intention was to share my experiences being the parent of a child living with diabetes in a new medium and hopefully to a wider audience. That was it, no larger or grander plan. I was just starting a podcast. Since then the podcast has reached more people than I could have ever imagined and the response from listeners is largely very positive. Better still, I receive emails, FB messages and tags on Instagram nearly daily from people who want to tell me how the podcast has helped them - those notes are unimaginably wonderful to read. The idea that a persons A1c is lower and more stable, that their life feels calmer and easier to enjoy... that feeling is well beyond any initial hope that I had for this blog or the podcast. I can't lie and tell you that I didn't think the podcast would be helpful but I wasn't able to imagine to what extent or that it would actually also help me.

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So how did we get to 5.7? The simple answer is by doing the podcast. It turns out that by taking the time to record the show, by having conversations with other people living with diabetes... I was allowing myself time to consider aspects of my management theories as well. Pausing life for a moment to think about type 1 and how to best approach it. I'm not a pre-planner at heart, I go and work things out as I'm moving. So some of the tactics that you have adopted through the Juicebox Podcast are things that occurred to me while recording the podcast. I took my experiences and spoke about them, during those conversations things came to me that previously had not. My ideas were growing and taking shape as I was sharing them with you. I learned from diabetes, you learned from me and I learned from you. A circle, a wonderful blue circle.

When I decided to stop being afraid of insulin, others followed. You had great success with that idea, I was enthused by your stories. That enthusiasm helped me to chase more fancy, find success and report it back to you. In return you contacted me and some of you come on the podcast to talk about your experiences - another blue circle. When I hear from you that the podcast is helping in your life, that knowledge supports me and we move forward together.

That is what community is...

I cried when one of you told me that your daughter has been playing for hours with a stable blood sugar. Your words, "she seems like herself again" striking me at my core. This exchange is one of the great moments of my life. All I want is for my daughter to have a chance to be herself and live her life. That a podcast was able to bring that dream to another person has made my heart soar.

There are many other stories and when each of them reaches me my desire to continue doubles. You all are the reason that Arden's A1c is 5.7, I have no doubt of that fact. I need to thank each of you and I want to invite you to come with me as I try to keep Arden's BGs stable, her A1c constant and try to make all of our lives better.

The Juicebox Podcast is one of the true surprises of my life. I just never imagined... 

I understand that not everyone knows about podcasts or how to find them but it couldn't be simpler. iOS users on iPhone and iPad only need to click this link, you already have a podcast app. Android and Google Play folks can click here. You can also listen online at JuiceboxPodcast.com, on Stitcher, iHeart Radio or in your favorite podcast app. Start at the beginning and take the journey with me, you'll catch up to subscribers in no time. The podcast is 100% free, I offset my costs by accepting ads on the show. It will never cost you anything to listen to the JBP.

If the podcast has helped you please consider leaving a comment below so that others may find the support they need to try an episode. #A1cYaLater #BoldwithInsulin #DiabetesandFear #TellAFriend