#460 Defining Diabetes: MODY Diabetes

March 30, 2021Scott Benner

Scott and Jenny Smith define diabetes terms

In this Defining Diabetes episode, Scott and Jenny explain MODY Diabetes (Maturity Onset Diabetes of the Young)

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DISCLAIMER: This text is the output of AI based transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate due to inaudible passages or transcription errors and should not be treated as an authoritative record. Nothing that you read here constitutes advice medical or otherwise. Always consult with a healthcare professional before making changes to a healthcare plan.

Scott Benner 0:00
Hello friends and welcome to Episode 460 of the Juicebox Podcast today is another in the defining diabetes series. It's short, it's sweet, and it's informative.

I've been defining diabetes here on the Juicebox Podcast for ever It feels like and I've done simple terms like Pre-Bolus a one c, Basal and Bolus. We also talked about honeymooning and things that people don't like to talk about. We've defined non compliant, brittle diabetes, and even talked about terms that are specific to the podcast like stopping the arrows trust will happen feeding insulin bumping and nudging. These episodes are chock full of good information. They're short and digestible. And if that wasn't enough, they're made even better with the presence of Jenny Smith, my friend and certified diabetes educator who helps me on these and the pro tip episodes. So today, Jenny and I are going to define Modi diabetes, Mo d y. While you're listening to that definition, with Jenny and I, please remember that nothing you hear on the Juicebox Podcast should be considered advice, medical or otherwise, always consult a physician before making any changes to your health care plan. were becoming bold with insulin.

If you enjoy this episode, look for the other defining diabetes episodes. Right there in your podcast player, you can just search Juicebox Podcast defining diabetes, and you will get a super long list of them. You can also find them at Juicebox Podcast calm and diabetes pro tip com. Speaking of websites, if you go to integrated diabetes comm you'll be at the place where Jennifer Smith works. There you'll learn things like Jennifer Smith has had Type One Diabetes since she was a child. Did you know that it's true over 30 years Jenny's had type one, she holds a bachelor's degree in human nutrition and biology from the University of Wisconsin. She's a registered and licensed dietitian and certified diabetes educator and a certified trainer on most makes and models of insulin pumps, and continuous glucose monitoring system. She also cheats at Scrabble. That's not true. I just never say anything bad about Jenny. And I thought that would be funny. But even as I said it, it felt wrong. Not gonna have a bunch of ads today just want to remind you to go to the T one D exchange, fill out their survey, help other people with type one diabetes, it is free for you, of course, because you're the one doing the thing. It is 100% HIPAA compliant. It is 1,000% anonymous. And if you want to remove your answers at any time, you can so easy thing to do. Why would you do this? Because the decisions that are made with your answers help people living with Type One Diabetes, all you need to be is a type one who's living in America, or the caregiver of a type one who lives in the United States. And you can go do this right now. T one d exchange.org. forward slash juicebox. Everyone who completes the survey is benefiting people living with type one diabetes, and you're benefiting the show a little bit too. So thank you for that. Okay, so we'll move on to the next one, which is Modi. So I can only recall he thought it was interesting. Yeah. Because this is even worse, right? I mean, more word like so maturity onset diabetes of the young. Mm hmm. See now Jenny, right off the bat. It says mature and young at the same time. These words don't go together. What does this know?

Jennifer Smith, CDE 3:50
And I've thought that myself, okay. I don't think I don't love Modi title or what it what it stands for, because you're right, mature and young. How do those go together really the diagnostic typical age. This is where it comes from is somewhere between about like 10, like pre puberty all the way through like the mid 40s. So your like kind of second decade through the fourth fifth ish decade of life is the typical diagnostic time period. Formally, okay. Okay. I've worked with only two people with Modi. Both of them I've worked with through pregnancy. Okay. And it's been really interesting. I mean, one who has had Modi she was diagnosed very early as a child with Modi had really good like, I guess, like tracking care in terms of like, you know how to manage. But it's a really, it's interesting because it's very rare. This is where Modi is similar, more similar to like that type two, in that there's not a, there's not an autoimmune component to it. So in, if you're checking antibodies, somebody with Modi may look, the type one, Ill, but they won't have antibodies

Scott Benner 5:25
type two. So this is just from Harvard health. But it says maturity onset diabetes of the young Modi is an inherited form of diabetes mellitus is caused by a change in one of 11 genes, up to 5% of all diabetes cases may be due to Modi. Just like other people, diabetes, people with Modi have trouble regulating their blood sugar levels. So like,

Jennifer Smith, CDE 5:47
and this is another I don't know if this is in your facts. But I remember reading not long ago, that I believe it's adults who are diagnosed with type one, almost, I think it's 80% of them have actual, like, Modi I would have to relook for that fact. But I, I'm sure it's struck me I was like, really, does that mean that a lot of people like walking around with like adult like, it was a really interesting fact, I'll have to look for it. Again. If I can find it

Scott Benner 6:23
says here that it's a it's a monogenic disease, meaning that it's caused by a single gene mutation. So you actually have a gene changes, one of 11 genes changes, it could be any number, any one of those 11. And now suddenly, I have all the same symptoms of somebody with Type One Diabetes. That's, that's kind of up. We'll just bleep that out later. But there shouldn't be multiple ways to end up with it should just be one way. How is it diagnosed a blood sugar test? So it's the same thing really like? So there could be tons of people who have this who don't know it, because it just it looks exactly like type one that would come autoimmune.

Jennifer Smith, CDE 7:06
It does. Oftentimes, though, and this is where proper diagnosis is really important. Because the different types of medication management for Modi differ depending on that genetic mutation, like the reason for their Modi really, some of them do very, very well, if diagnosed correctly, more so on oral medications and lifestyle change much similar to a type two, oh, and then there are some that do much better with other like insulin, may nessus, may be needed more similar to a type one, but they don't have they don't have that antibody component that would designate them truly as type one.

Scott Benner 7:52
No kidding. Well, that's weird.

Jennifer Smith, CDE 7:54
Yeah. And the other interesting thing is the C peptides, which sort of are a measure of your own pancreatic beta cell action, and like pop out of insulin, right, in someone with Modi, as well as with type two, they have normal range of beta cell action, they have normal range of C peptide levels, whereas in somebody with type one, their c peptide levels are below a normal level or almost undetectable.

Unknown Speaker 8:33
So

Scott Benner 8:33
I feel like if you tell me that we have described Modi completely, that we're going to take a little minute here and do this again with C peptide. Can you do that?

Unknown Speaker 8:45
Sure. Yeah.

Scott Benner 8:46
All right. Yeah. Do you think we did Modi? Okay.

Jennifer Smith, CDE 8:49
I think so. I mean, from the general of what we can give to people there are, there are very they're very few, I guess, good plate. I know that I think it's the University of Chicago that actually has a Modi tracking system so that you can actually they log patients who have diagnosed Modi, which is interesting. But yeah, I think in definition, I think we did a good job.

Scott Benner 9:20
Thank you. And it looks like something I just thank you. Like I said anything except the only thing I had listened to everybody listening knows the only thing I added to this was I said the Jenny, I think we should define Modi in one of the episodes Other than that, I've got nothing to do with this. But I did just Google Modi testing. And quest diagnostics is a laboratory that I think is all over America. And it's funny how they're starting to pop up because they describe all the testing they do. So there is a test for it. So a doctor can do a blood to draw that would tell you and they have a couple of little pieces of information it says Modi 2% of all diabetes cases. So they think there's a half a million people with AI with Modi and 90% of Modi cases are mis diagnosed type one or type two. Well, yeah,

Unknown Speaker 10:08
there. There it is. Yeah. Okay, something right.

Scott Benner 10:11
All right, cool. Huge thanks to Jenny for lending her brilliance to the Juicebox Podcast. Don't forget to check her out at integrated diabetes comm you can actually hire Jenny and she'll help you with your diabetes. Thanks also to all the sponsors that I didn't mention today. And what else, check out the T one D exchange a T one d exchange.org Ford slash juice box. Take the survey, fill it out, help people with type one diabetes help the show feel good about yourself takes a few minutes to do something nice. If you hold on for a second after the music, I'll go over where the diabetes pro tip episodes are. The defining diabetes episodes how you can listen in a podcast player if you're listening online and all the other stuff that new listeners and interested parties should know. So here's how it goes. If you want to check out the Omni pod, the Dexcom de veau hypo pen, T one D exchange touched by type one with a Contour Next One blood glucose meter, I'd appreciate it if you use my links. They're right there in the podcast player show notes. You can also find them at Juicebox Podcast comm where you can type them into a browser. And at the very end of this, I'll leave them if you want to hear them. But I imagine you're gonna shut it off before I say that. But still, I'll put them there for you. Now the diabetes pro tip episodes, for those of you who listen in a podcast player, they're right there. You can just search diabetes pro tip, and the words Juicebox Podcast and you're going to get them all. But you can also find them at diabetes pro tip.com. When you get there, you're going to see that they that the pro tip episodes begin at Episode 210 with an episode called diabetes pro tip newly diagnosed or starting over. And then they go on for their protests began back in February of 2019. And there was a new one put up as recently as March 5 2021. So it's a really great list of episodes that will help you manage your diabetes, the way you hear us talking about it here. And these defining diabetes episodes are also incredibly helpful. Right now the way diabetes pro tip comm is set up. If you scroll down a little bit, you can find those as well. There's also ask Scott and Jenny shows the latest episodes of the podcast. It's all right there. Actually. There's also links to places where you can listen through an app. So I know some people don't listen to a lot of podcasts. And this could be new for them. But you can listen in a free application. If you're on Apple, Spotify, amazon music, Google podcasts, Pandora, any apps that are available on Android, just keep in mind that podcast apps should not cost you money. So my links will take you to a number of apps that are free and work great. Otherwise, you can listen pretty much anywhere you get audio. If you're listening in an app now please like follow subscribe, whatever your app allows you to do. And you will get three new episodes of the Juicebox Podcast every week to choose from, even listen to them all. Listen to some of them. Whatever works best for you. If you're looking for people chatting about management, you should look no farther than the Facebook page for the Juicebox Podcast. It's called Juicebox Podcast type one diabetes. It's a private group. So you can talk freely. Go find that if you're looking for a 10,000 users now. It's a really terrific place to talk about using insulin, and all the things that come up when you have type one. I'm also on Instagram. I don't do much on Twitter, but it's there at Juicebox Podcast. And let me just say thank you one more time, it's the end of March 2021. This month, did 120% better than march of 2015. This was the most downloaded month in the history of the podcast. In fact, it had 15.38% more downloads than the previous month, February 2021. So let me thank you again for sharing the show for subscribing in a podcast app. And for generally just being the most supportive group of people I could ever hope for. I'll talk to you soon. I should be back in like two days with another episode. So hold tight. There's more coming